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Mechanism of Action and Direct Metabolic Effects Semaglutide works by mimicking the naturally occurring GLP-1 hormone, which enhances glucose-dependent insulin secretion from pancreatic beta cells and suppresses inappropriate glucagon release

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Diabetes Obes Metab 19:2432 Vilsboll T, Christensen M, Junker AE et al (2012) Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials