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The binding of T3 to TRs induces a conformational change in the receptor, which allows the receptor to bind to thyroid hormone response elements (TREs, specific DNA sequences) in the promoter regions of target genes (Simons 2003)

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doi: 10.3390/microorganisms8020269 555 CrookNFerreiroAGasparriniAJPeseskyMWGibsonMKWangBet al

Together, these phenotypes clearly show that targeted disruption of components of glutamatergic synapses within the CSTC circuitry can produce anxiety and compulsive behaviors