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He says there's very little data on whether or how the dose should be titrated to wean patients off, or how to adjust when your appetite and cravings start to return

Body Contouring Treatments : Sometimes significant weight loss results in excess, sagging skin

Interestingly, the same study found that, in rats, tirzepatide suppressed lipid intake without affecting sucrose (carbohydrate) consumption in a choice-based assay, implying that the effects of these medications may be macronutrient specific (Geisler et al., 2023)