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Lipodystrophy (indented or thickened tissue at injection sites) develops over months of repeated injections in the same spot, which is why site rotation is essential

Further, a typical meal take 60-90 minutes to pass through the stomach

At higher concentrations, the peptide molecules are packed more closely together, which can increase the rate of aggregation under thermal stress

Plus, tablets would be more portable than injection pens, and they dont have to be stored in the refrigerator

Data from the STEP trials demonstrate that weight loss often increases as the dose increases, with significant reductions typically occurring between months 2 and 6 of treatment