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Second, you can monitor side effects in a controlled way and adjust dosing before they become severe

The decision to switch weighs your response so far, side effects, other conditions, and cost, not a one-size-fits-all rule

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However, once a pen has been stored at room temperature for any period, the cumulative time must not exceed 28 days, and the pen should ideally be returned to refrigerated storage between 2C and 8C when possible