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For compounds where plasma half-life and biological effect duration differ significantly (such as BPC-157 and TB-500), a second curve displays the estimated biological signalling window separately from plasma clearance

This finding suggests that DPP4 inhibitors, owing to their GLP-1-enhancing actions, may have a direct beneficial effect on cardiomyocyte function

The PIONEER 4 trial showed participants lost 10% of their body weight at 68 weeks, and PIONEER 10 confirmed oral semaglutide produces comparable results to the weekly injection