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Although, the present study did not provide evidence for the involvement of Epac in OA- mediated PI hydrolysis, demonstration of Epac2 expression in STC-1 cells and published reports in other cell types support our conclusion about the role of Epac/PLC- pathway in Ca 2+ mobilization

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For the receptor mechanism that underlies this work, see how the GLP-1 receptor is structured and signals, and for how discovery connects to the wider therapeutic landscape, the full picture of GLP-1 and metabolic disease

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Dual GIP and GLP-1 Receptor Agonists A newer class extends the incretin mimetic concept by targeting both GLP-1 and GIP receptors simultaneously