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We see gradual, progressive loss of subcutaneous fat, degradation of collagen and elastin, and a flattening of the cheeks due to loss of malar projection, all of which contribute to an aged appearance. Weight loss induced by GLP-1 medications, however, accelerates these changes

Figure 27: Photograph of Sir James Black (1924-2010), credit: Lyall

Inhibition of ASAH2 led to increased p53 protein stability, upregulation of Hmox1 expression, suppression of ROS generation, and MDSC death via iron-dependent lipid peroxidation

The development of pH-responsive NPs and engineered probiotic factories marks a new frontier in IBD therapy, with potential to reduce reliance on corticosteroids and biologics

(2019) 3:e2639