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The androgen receptor (AR) signaling axis may influence the expression profile of LPA (unspecified species)-producing enzymes: androgen-sensitive LNCaP cells predominantly express AGK, whereas androgen-insensitive PC-3 and DU145 cells express ATX (69), raising the possibility that PTEN deficiency might indirectly augment the LPA pathway, though direct transcriptional regulation has not been demonstrated

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Huang T, Zhang K, Sun L, et al