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This interaction with GHSR-1a leads to a GH release from the pituitary gland , which can influence several anabolic processes including appetite regulation, fat processing, and overall energy usage (1)

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Compared to 25(OH)D, this metabolite can bind to it far more readily (40)

That is, a reasonable target at one time point during development may be inappropriate at another time point because of structural and functional changes based on neuronal migration, circuit connectivity, synaptic plasticity, and gene expression

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