does semaglutide or tirzepatide have worse side effects vs. for Weight Loss GLP-1 Side Effects: What's Normal

A researcher transitioning from compounded tirzepatide 10 mg weekly (using a 20 mg/mL vial) to semaglutide 1 mg weekly (using a 5 mg/mL vial) goes from injecting 0.5 mL of tirzepatide to 0.2 mL of semaglutide

Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress. Nutrients, vol

The specific risks and actions to take are explained below

Headaches , sulfur burps , fatigue , and constipation are the most common issues

Patients should contact their GP or diabetes specialist nurse if they experience: Red flag symptoms requiring urgent assessment: Severe, persistent abdominal pain , particularly if localised or accompanied by fever, which could indicate pancreatitis (a rare but serious adverse effect of GLP-1 receptor agonists)