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A meta-analysis covering over 28,000 patients found that while the overall rate of GI adverse events was similar (approximately 5253% of patients in both groups), serious adverse events occurred somewhat more frequently with higher tirzepatide doses (5.37% at 1015 mg) compared to semaglutide (2.8%)

Guidelines for Safe and Effective Use : Follow your healthcare provider's instructions and the semaglutide prescribing information

The Journal of the Pakistan Medical Association

This alteration doesn't prevent you from taking semaglutide or tirzepatide, but it does mean your digestive system processes these compounds differently than someone with an intact gallbladder