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In EAE mice, adoptive transfer of itaconate-treated, Th17-polarized T cells significantly ameliorated disease severity (173), highlighting the potential of targeting metabolic pathways to modulate the Th17/Treg balance in autoimmune neuroinflammation

The redox electrode was calibrated using ZoBells solution (2.64 g K 4 [Fe(CN) 6 ].3H 2 O and 2.06 g K 3 [Fe(CN) 6 ].H 2 O dissolved in 500 mL pH = 7 0.15 mol/L Na 2 HPO 4 /KH 2 PO 4 buffer)

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The concurrent inhibition of MEK (trametinib) and glutamine metabolism (V-9302) enhances antitumor efficacy by orchestrating the FOXO3a/FOXM1 axis and autophagy, leading to pyroptosis and cell cycle arrest (135)

More exciting still, carnitine supplementation had a positive effect on catch-up growth, with the infants regaining their birth weight more rapidly than the placebo group (without carnitine supplementation)