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It can be used as monotherapy when metformin is inappropriate, or in combination with other glucose-lowering medicinal products, including insulin, when these alone are inadequate

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FIGURE 1 N -methyltransferase

Semaglutide, for example, has also been approved for T2DM in tablet form but this oral peptide formulation must be taken on an empty stomach first thing in the morning, with food and water restricted for 30 minutes afterwards

Some research has raised concerns about potential negative effects on insulin sensitivity and liver fat with long-term use