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154 However, HIF-1 in islets is decreased in T2D, by hyperglycemia through inhibiting the HIF-1-HIF-1 dimer formation, and by NEFAs through increasing the proteolysis, leading to inability to initiate hypoxic adaptive responses

[DOI] [PubMed] [Google Scholar] 42.Bunschoten C., Jacobs B.C., Van den Bergh P.Y.K., Cornblath D.R., van Doorn P.A

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Sincere thanks are also given to all volunteers and patients who participated in clinical studies with Pycnogenol