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The cellular mechanism by which the releasing hormones affect GH secretion from the somatotrope requires specific signal transduction systems (cAMP and/or calcium influx and/or mobilization of intracellular calcium) and/ or tyrosine kinase(s) and/or nitric oxide (NO)/cGMP

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For signals to be sent from neuron to neuron, not only does the neurotransmitter have to be released into the synapse, but it also has to be received in a receptor, which then sets off a chain of events to send on the signal

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