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[11] Use is not recommended in those who are allergic to cobalt or have Leber's disease

doi:10.1146/ annurev.bi.57.070188.001401 [DOI] [PubMed] [Google Scholar] 41.Baci D, Bruno A, Bassani B, et al

Pyridoxine also antagonizes the effects of levodopa when levodopa is used without a dopa-decarboxylase inhibitor (such as carbidopa)

292,293 This fact indicates the redundant functions of various signaling pathways that limit the therapeutic efficiency of targeting signaling molecules