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Acknowledgements This work was supported in part by the China Postdoctoral Science Foundation (2015M570745 and 2016T90815), Natural Science Foundation of Guangdong Province (2016A030310229), National Natural Science Foundation of China (81602634), and the Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (ZIA EB000073)

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Funding for medical writing services was provided by Novo Nordisk, Inc

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