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Heavier individuals may need higher absolute doses to achieve equivalent tissue concentrations, while lighter individuals may find lower doses sufficient

In a randomized trial, 74 RA patients were given either 600 mg of NAC or a placebo twice daily for three months

Evidence for skin lightening with oral glutathione is mixed and usually tied to higher doses or nonoral routes

In the bird, male brain-derived estrogens are both necessary and sufficient for establishment of the song control circuit, a sexually dimorphic behavioral response (97)

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