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It can be induced to undergo endoplasmic reticulum stress in response to inflammation, oxidative stress, and hypoxia, thereby regulating intracellular environmental homeostasis through unfolded protein responses

J Biol Chem 286(30):2651626523 Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Spiegelman BM (2010) Transcriptional control of preadipocyte determination by Zfp423