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375,377 Importantly, 753b and PZ15227 can prevent the platelet toxicity caused by the first-generation Bcl-xL/Bcl-2 dual inhibitor navitoclax

Acral lentiginous melanomas are overrepresented, and SCCs may exhibit more aggressive behavior, with metastasis to lymph nodes and internal organs.[228,231] Pathogenic variants in the WRN gene on chromosome 8p12-p11.2 have been identified in approximately 90% of individuals with this syndrome

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In high-fructose cultured human podocytes (HPCs), the upregulation of Sp1 promotes the expression of HDAC4 and leads to the disappearance of the foot process and the intensification of the inflammatory response

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