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DMF- and Clem-F-mediated Plp1 expression was reduced in the presence of Gsta4-specific siRNA (siRNA-Gsta4) knockdown (Fig

Some of the indicators of oxidative damage that have been observed in the striatum and cerebral cortex of patients with HD are an increase in the concentration of Antioxidants 2023,12, 834 15 of 24 malondialdehyde (MDA) and 4-hydroxynonenal (lipid oxidation products), increase in carbonylation and in protein nitration, as well as a decrease in GSH and an increase in the activity of glutathione peroxidase, catalase, and superoxide dismutase [184]

[DOI] [PubMed] [Google Scholar] 27.Ferrazzano L., Catani M., Cavazzini A., Martelli G., Corbisiero D., Cantelmi P., Fantoni T., Mattellone A., De Luca C., Felletti S., et al

It also serves as a cofactor for enzymes involved in DNA maintenance, cellular stress responses and metabolic balance