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Editor information Editors and Affiliations Rights and permissions Copyright information 2015 Springer-Verlag Berlin Heidelberg About this entry Cite this entry Pickart, L., Vasquez-Soltero, J.M., Margolina, A

This creates a receptor availability window: administering IGF-1 LR3 during peak receptor density maximizes binding efficiency, while administration during receptor downregulation produces spillover binding to insulin receptors

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