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While these mechanisms make them highly effective, they also predispose patients to gastrointestinal adverse effects, such as nausea, vomiting, abdominal discomfort, and constipation

As in the prior GLP-1 trials reviewed, the GI side effects early that include vomiting, diarrhea, nausea, and constipation, occur in about half of the participants with initial dosing

While the expression of Glp1r in the pylorus was similar, levels of cAMP in response to GLP-1 stimulation were decreased in the pylorus of PamKO mice compared to wildtype littermates (Fig

However, it is prohibited by WADA for competitive athletes and is not approved for human consumption