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221 Furthermore, two natural substances, nerodol and citrus peel polyphenols, have been shown to improve the pathological state of UC mice and protect the integrity of the intestinal barrier by suppressing the activation of the NF-B pathway

8 A case-control study that compared 25,956 patients who had vitamin B 12 deficiency with 184,199 control patients found a significantly increased risk of vitamin B 12 deficiency in patients who had taken proton pump inhibitors (odds ratio = 1.65) or histamine H 2 blockers (odds ratio = 1.25) for at least two years

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Similar phenotypes were also observed when GCLC was deleted in HCC-1806 cells (a human breast cancer cell line), which showed complete depletion of GSH levels (Fig