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Catalase is an important enzyme responsible for the neutralization of hydrogen peroxide (H 2 O 2 ), a non-radical reactive oxygen species (ROS), hence, maintaining an optimum level of H 2 O 2 in the cell

But it appears that such an antioxidant response may occur in the C57BL/6J mouse brain that prevented the increase in brain pyruvate levels and the changes in the malate/pyruvate and the pyruvate/lactate that occurred in the aged C57BL/6N mouse brain (Ding et al., 2021)

Every time the door opens, cold air escapes and warm air enters

However, ultimately it is imperative to elucidate the primary, upstream mechanisms responsible for neurodegeneration in ALS so that effective therapeutics can be designed

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