Silibinin and non-melanoma skin cancers
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48 In line with this, recent evidence has indicated that MT1M has the ability to dampen the malignancy and stem cell-like characteristics of GC by inhibiting GLI1, a component of the Hedgehog signaling pathway, known for its numerous zinc finger domains
Funding This investigation was supported by the National Natural Science Foundation of China (grant number: 82200304), the Natural Science Foundation of Heilongjiang Province (grant number: PL2025H107), Heilongjiang Provincial Universities Outstanding Young Faculty Basic Research Support Program (grant number: YQJH2025132), China Heart House-Chinese Cardiovascular Association-2024 TCM fund (grant number: 2024-CCA-TCM-030)
However, two large trials performed in USA have shown that these benefits are no longer seen in patients whose baseline serum selenium concentration was above 122 g/L, in whom, conversely, these risks were increased