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Research Models and What a Convincing Trial Would Require Understanding why the answer to the title remains indicative, not proven is easier once you see how the compound has been studied and what a definitive study would demand

Extrapolating preclinical findings to human physiology carries inherent uncertainty

CONTRAINDICATIONS Sensitivity to cobalt and/or vitamin B 12 is a contraindication

Lifestyle Factors: Because cigarette smoking and excessive alcohol intake cause an increase in free radical production, both habits deplete glutathione levels

Increased nitrosative and oxidative stress in platelets of migraine patients