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Similarly, pS6K levels were significantly upregulated in HG-treated HRMC cells and improved by HU treatment (Figures 7C, D)

Discontinuation due to TEAEs was dose-dependent, rising from 6% at 2.5 mg to 20% at 15 mg, with the 5 mg and 10 mg arms at 11%-14% respectively for TEAE-driven withdrawal

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