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At the whole leaf level o thef Arabidopsis wildtype, increase in photo-protective anthocyanins was visible in plants grown at 300 mol m 2 s 1 , which was more pronounced, but also accompanied by small necrotic lesions at leaf edges at 700 mol m 2 s 1 , and intensified even more at 1500 mol m 2 s 1 , while the photosynthesis-associated pigments (chlorophyll and carotenoids) were reduced (Heyneke et al

doi: 10.1038/s43018-021-00297-3

Problem : Degrades within days, loses effectiveness

A higher AUC was achieved with Berberine-loaded chitosan/SLN nanoparticles (2,926 75 ng/h/mL) as compared with free berberine (692 74 ng/h/mL)

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