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PMID 15298442

As noted by Kraus et al., Nature Medicine and Ng et al., Journal of Endocrinology , targeting both systemic metabolism and localized fat cell activity may enhance fat-loss outcomes beyond either approach alone

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Thus, under obese conditions, inhibition of antioxidant enzyme pathways may cause ferroptosis in activated Treg cells, decreasing their number and increasing inflammation and metabolic disorders (156)