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One of the medications used to treat type 2 diabetes (T2DM) is glucagon-like peptide 1 receptor agonists (GLP-1RAs) which have multiple effects, including weight loss

Since TA and KGN could regulate in situ inflammation reactions and induce BMSCs to differentiate into chondrocytes, respectively, the ability to repair cartilage defects was improved

Retatrutide is an investigational once-weekly injectable developed by Eli Lilly that simultaneously activates three hormone receptors GLP-1, GIP, and glucagon making it the first drug in clinical development to target all three pathways at once

No hype, just mechanisms, then a clear path

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