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Melanie Jay, MD, MS Post Every week, patients ask me: Are GLP-1 drugs safe? Will I regain the weight? Could this help me live longer? I recently joined Anthony Manson on Medicine in America Podcast on ElectraCast Media to discuss: What GLP-1 medications actually do , and how they work Who is (and is not) an appropriate candidate Risks, side effects, and long-term considerations Whether these medications may influence lifespan What this moment means for clinicians, patients, and health systems As an obesity medicine physician and researcher, I believe we need thoughtful, evidence-based conversations about these treatments grounded in science