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The statistical analysis plan (SAP) specified a crossover mixed model repeated measures (MMRM) analysis, which took into account multiple comparisons, using the restricted maximum likelihood estimator (REML) as estimation method and structured covariance matrix with compound symmetry and included all data from those completing ( n = 13 per dose) both treatment periods (first period A and second period B)

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Experimental Protective Role : May protect the digestive system from injury caused by medications (NSAIDs) or environmental toxins