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Type 2 diabetes typically occurs when the body is not producing a sufficient amount of insulin, which keeps glucose in the bloodstream instead of being used as energy
However, the carbonic anhydrase 8 (CAR8), which is highly expressed in L-cells, has been found to reduce GLP-1 secretion in response to LCFAs
It also drives cravings for high-sugar, high-fat foods by stimulating the same reward pathways that GLP-1 medications work to quiet
Nausea, diarrhea, and vomiting are the most common
Pramlintide, a synthetic analog of human amylin, improves the metabolic profile of patients with type 2 diabetes using insulin
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