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We searched PubMed and Google Scholar as electronic databases using the combination of the terms lipid metabolism, inflammation, and depression with the following keywords: lipid dysregulation, obesity, MDD, neuroinflammation, omega-3, cholesterol, gene, gut microbiota, adipose tissue, BBB, Hypothalamic-pituitary-adrenal (HPA), insulin resistance, leptin, adiponectin, brain, and CNS, mitochondrial dysfunction, endoplasmic reticulum stress (ER stress)

We found that 5-MTHF supplementation is also less likely to cause hematological symptoms associated with vitamin B12 deficiency [170]

Semaglutide: Targets the brain centers that regulate appetite, especially after eating, which may help you eat less

These conditions can cause imbalances in the systems regulating your peptides and hormones

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