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Researchers should anticipate that the glucagon receptor-mediated effects on energy expenditure may manifest earlier in some assays than the full appetite-suppressing effects, given the different tissue distributions of the three receptor types
Retatrutide, Lillys follow-on molecule, is a triple agonist that adds the glucagon receptor to the same dual backbone and, in its first Phase 3 readout, produced the deepest weight reduction ever reported in a registrational obesity trial: about 28.7% at 68 weeks 5 vs tirzepatides SURMOUNT-1 peak of roughly 22.5% at 72 weeks 13
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