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A GHRH stimulation test using 1 mcg/kg IV sermorelin (the historical Geref diagnostic dose) can distinguish partial from complete pituitary insufficiency, though this diagnostic application is also now off-label following Geref's market withdrawal

These special programs slightly deviate from Optavia's original 5&1 plan that first debuted in 2017 and can be further customized by a health care professional to accommodate symptoms of underlying conditions

10.1523/JNEUROSCI.1607-04.2004 J

Researchers monitor patients for any adverse effects, documenting both common and rare side effects

doi: 10.1016/j.physbeh.2013.04.003