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167 Lactobacillus L15 and Lactobacillus C4 can also protect the integrity of the intestinal barrier by decreasing the expression levels of proinflammatory cytokines and upregulating the expression of tight junction proteins and mucin-2 (MUC2)

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Collectively, these research advancements underscore curcumin's robust neuroprotective profile and its potential as a natural, multifaceted therapeutic agent for AD, with ongoing clinical studies focused on optimizing delivery and dosing strategies to overcome bioavailability challenges and maximize clinical benefits