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These findings emphasize that targeted antagonism of NMDA receptor signalling lowers body weight independently of MC4R, indicating that this preclinical drug candidate might not only be effective in treating polygenic obesity but also holds potential as an effective weight loss strategy for patients with loss-of-function mutations in MC4R , the most common form of monogenic obesity 32

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These alterations in the FFG and PCC may influence facial and emotional processing, potentially contributing to the social deficits observed in autistic individuals (136)

There were no differences in mean age, gender or post-mortem interval between the autism and control groups for either cerebellum or BA22