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The newest one was approved in 1994

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In clinical trials, about 5.4% of patients discontinued Wegovy at the highest 7.2 mg dose due to side effects, compared with 6.2% of participants on Mounjaro 15 mg

JC-1 staining of 4T1 cells as a measure of mitochondrial depolarization after different therapies

With portfolio value consolidating into these fewer, larger assets and the cost to develop them continuing to climb there is a precarious balance of high potential returns and the risk of significant value destruction from a single program failure