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For instance, KYNA-GRP35 interactions were demonstrated to lessen the LPS-induced pro-inflammatory state, decreasing concentrations of TNF- and HMGB1 [125]

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All in vitro experiments were repeated three times with similar results

As such, glomerular lesions occur which include glomerular basement membrane thickening, podocyte effacement and loss, mesangial expansion, epithelialmesenchymal transition EMT and fibrosis, collagen deposition, damage to the capillary architecture and an influx of inflammatory cells including macrophages