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Article contents Abstract Physiological changes in pregnancy affecting B-vitamin biomarkers B-vitamin biomarkers during pregnancy Recommendations for B-vitamin intake in pregnancy Clinical implications of B-vitamins in pregnancy Conclusions Ethics of human subject participation Financial support Conflicts of interest Authorship References B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges Published online by Cambridge University Press: 23 September 2024 Abstract Physiological changes in pregnancy affecting B-vitamin biomarkers B-vitamin biomarkers during pregnancy Recommendations for B-vitamin intake in pregnancy Clinical implications of B-vitamins in pregnancy Conclusions Ethics of human subject participation Financial support Conflicts of interest Authorship References Abstract Folate, vitamin B12, vitamin B6 and riboflavin interact by functioning as cofactors within one-carbon metabolism (OCM), a network of interrelated cellular pathways essential for numerous biological processes, including the biosynthesis of DNA, amino acid interconversions and methylation reactions

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It was approved for type 2 diabetes in the USA in 2017 and in Canada and Europe in 2018 for 1 mg SEM administered subcutaneously once weekly, exhibiting a safety profile similar to other antidiabetic agents and offering additional advantages [21,22]