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While there was moderate statistical heterogeneity for three-point MACE in these analyses, there was no evidence of subgroup differences based on the pharmacologic characteristics of studied agents or the baseline characteristics of adults enrolled in the clinical trials

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Their evidence base comes from trial programs such as STEP (semaglutide for weight management, published in The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

doi: 10.1038/s41392-020-00374-6 3 Abdool KarimS

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