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By enhancing the active transport of long-chain fatty acids into the mitochondrial matrix via the carnitine shuttle, L-carnitine supplementation supports robust, sustained beta-oxidation

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Changes in the local microenvironment within metabolic organs have a significant impact on the function of tissue-resident and newly recruited macrophages, leading to metabolic inflammation linked to obesity (Wculek et al., 2022)

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Retatrutide does it via GLP-1 receptor activation in the gut and CNS