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Wegovy was in short supply during much of 2022 because of a manufacturing problem, which fueled the demand for alternatives such as Ozempic and Mounjaro, leading to shortages at times for those drugs, too

Some patients pay for treatments because insurance rules can be more demanding

None of the above peptides have gone through one

GLP-1 receptor agonists significantly lowered CRP levels (standardised mean difference of 0.39) and TNF- levels (SMD of 0.51), with longer treatment durations yielding more noticeable benefits, according to a thorough meta-analysis published in 2025 that synthesised 25 studies involving 1,878 patients with type 2 diabetes

TB-500 remains a 503A Category-2 bulk substance, while BPC-157 was removed from the 503A list in April 2026 and is under PCAC review