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A survival response of mammalian cells
LOXs, a family of iron-containing proteins, can catalyze the peroxidation of PUFAs on cell membranes, inducing cell death via ferroptosis
Subsecuentemente, la activacin de vas de sealizacin secundarias, incluyendo protena quinasa A (PKA) y Epac2, alteran la actividad de los canales de iones celulares, causando niveles elevados de calcio citoslico que aumentan la exocitosis de grnulos contenedores de insulina
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