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A metabolic phenotype (strong insulin resistance, weight gain, elevated fasting insulin) is most likely to benefit from GLP-1 therapy

How NAD+ injections work in the body Once injected, NAD+ is absorbed into capillary beds in the tissue and enters systemic circulation

The most recently approved type, tirzepatide [archived link], is called a dual agonist because it mimics the effects of two gut hormones, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)