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The most commonly cited starting protocol in the medical literature and clinical practice involves 250 micrograms administered once daily for acute injury, stepping up to 500 micrograms daily if response is insufficient after one to two weeks

(7) The effect was dose-dependent

Ogilvie: Some of these peptides will be degraded in lysosomes, so we use a human liver lysosome fraction just for screening, or to try to modify them to make them more stable, so they have a longer half-life and can be injected less frequently

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