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All-trans retinoic acid (ATRA), a stereoisomeric form of retinoic acid, has been shown to inhibit POMC transactivation and ACTH secretion in murine corticotroph tumor AtT20 cells via inhibition of AP-1 and Nur transcriptional activities (32)

en datos obtenidos de animales presenta una vida media de eliminacin, aproximadamente de 16 horas

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Bipolar disorder In addition to schizophrenia, study demonstrated an association between homozygous 677TT genotype of MTHFR gene and bipolar disorder with stronger linkage in male patients than female patients 46

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